Frequently Asked Questions About OASIS® Ultra Tri-Layer Matrix
OASIS® Ultra is indicated for the management of diabetic, pressure, venous, and chronic vascular ulcers, trauma (including abrasions, lacerations, second-degree burns, and skin tears), draining, surgical (including donor sites/grafts, post-Mohs' surgery, post-laser surgery, podiatric, and wound dehiscence), and partial- and full-thickness wounds.
OASIS® Ultra is a natural extracellular matrix (ECM) derived from porcine small intestinal submucosa (SIS). The natural tissue scaffold is absorbed and incorporated into the wound environment. The unique design of OASIS Ultra® provides 3 layers of structure that help support the body’s healing process.
OASIS® Ultra Tri-Layer Matrix is indicated for the management of wounds including:
  • Partial- and full-thickness wounds
  • Pressure ulcers
  • Venous ulcers
  • Chronic vascular ulcers
  • Tunneled, undermined wounds
  • Diabetic ulcers
  • Trauma wounds (abrasions, lacerations, second-degree burns, skin tears)
  • Draining wounds
  • Surgical wounds (donor sites/grafts, post-Mohs' surgery, post-laser surgery, podiatric, wound dehiscence)
Small intestinal submucosa (SIS) is a specific layer of the small intestine that can help support the body's own natural healing mechanisms. OASIS® Wound Matrix is derived from porcine SIS1. More than 900 clinical and preclinical scientific publications cite the wide variety of benefits and uses of SIS.2
In the healthy body, the ECM is the structural complex that surrounds cells and binds them in tissue. Chronic wounds are often difficult to heal because the body’s natural ECM, a crucial component in the healing process, is damaged or failing.3,4 OASIS® Ultra contains multiple naturally occurring components of ECM.
OASIS® Ultra is comprised of the same structural components as OASIS® Wound Matrix (SIS/ECM). OASIS® Ultra provides added strength by incorporating 3 layers of SIS into the wound versus the single-layer SIS structure of OASIS® Wound Matrix. In addition, the extra thickness of OASIS® Ultra provides easier handling for surgeons.
OASIS® Ultra is available in 5 convenient sizes for application: 3x3.5, 3x7, 5x7, 7x10, and 7x20. Please visit our Application page or view our Application and Reapplication videos for full details on applying OASIS® Ultra.
Reapply OASIS® Ultra as needed. Reapplication is usually necessary every 7 days if OASIS® Ultra is no longer covering the wound and the wound is free of infection and necrosis.
When OASIS® Ultra is absorbed into the wound, a caramel-colored or off-white layer of gel may form over the surface of the wound. This caramelization is normal and continues to support the healing environment. Do not attempt to forcibly remove. Gently cleanse the wound with sterile saline and reapply additional sheets over previous applications as necessary.
Please visit our Ordering page for details.
OASIS® Ultra is supplied in sterile peel-open packages intended for one-time use, with a convenient shelf life of 24 months. It should be stored in a clean, dry location at room temperature. OASIS® Ultra offers off-the-shelf availability in 2 large sizes (7x10 and 7x20) and smaller sizes: 3x3.5, 3x7, and 5x7. No advance ordering or preparation time is required.
OASIS® Ultra is well tolerated in most patients. However, patients may experience the following complications: infection, chronic inflammation, allergic reaction, or excessive redness, pain, swelling, or blistering. If any of these side effects occur, remove OASIS® Ultra from the wound. Initial application of wound dressings may be associated with transient, mild, localized inflammation.
Please review the “Precautions” section of the OASIS® Ultra Instructions for Use.
OASIS® Ultra is safe to reapply as many times as necessary until the wound is fully closed or significant granulation has occurred. Discontinue use in the event of infection, chronic inflammation, allergic reaction, or excessive redness, pain, swelling, or blistering.

References: 1. Hodde JP, Janis A, Hiles M. Effects of sterilization on an extracellular matrix scaffold: part II. Bioactivity and matrix interaction. J Mater Sci Mater Med. 2007;18(4):545-550. 2. Data on file. Cook Biotech, Inc. 3. Mac Neil S. What role does the extracellular matrix serve in skin grafting and wound healing? Burns. 1994;20(Suppl 1):S67-S70. 4. Clark RA. Basics of cutaneous wound repair. J Dermatol Surg Oncol. 1993;19(8):693-706.


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