Frequently Asked Questions
OASIS® Wound Matrix is indicated for the management of diabetic, pressure, venous, and chronic vascular ulcers, trauma (including abrasions, lacerations, second-degree burns, and skin tears), draining, surgical (including donor sites/grafts, post-Mohs' surgery, post-laser surgery, podiatric, and wound dehiscence), and partial- and full-thickness wounds.
OASIS® Wound Matrix is not appropriate for patients with third-degree burns or in patients with known allergies to porcine materials.
OASIS® Wound Matrix is an extracellular matrix (ECM) naturally derived from porcine small intestinal submucosa (SIS). The natural tissue scaffold is incorporated and absorbed into the wound environment. Watch the OASIS® Wound Matrix Mechanism of Action Video for more information.
Small intestinal submucosa (SIS) is a specific layer of the small intestine that can help support the body's own natural healing mechanisms.1 OASIS® Wound Matrix is derived from porcine SIS. More than 900 clinical and preclinical scientific publications cite the wide variety of benefits and uses of SIS.2
In the healthy body, the ECM is the structural complex that surrounds cells and binds them in tissue.3,4 Chronic wounds are often difficult to heal because the body’s natural ECM, a crucial component in the healing process, is damaged or failing.
OASIS® Wound Matrix and OASIS® Ultra Tri-Layer Matrix are composed of the same structural components (SIS/ECM). While OASIS® Wound Matrix contains a single layer of SIS, OASIS® Ultra consists of 3 layers of the SIS matrix for more problematic wounds. Both are indicated for the management of wounds. To learn more about these products, please visit our About OASIS® Wound Matrix and About OASIS® Ultra pages.
Please visit our Application page for full details on applying OASIS® Wound Matrix.
Reapply OASIS® Wound Matrix as needed. Typically, reapplication is needed every 3 to 7 days if OASIS® Wound Matrix is no longer covering the wound and the wound is free of infection and necrosis.
When OASIS® Wound Matrix is absorbed into the wound, a caramel-colored or off-white layer of gel may form over the surface of the wound. This caramelization is normal. Do not attempt to forcibly remove. Gently cleanse the wound with sterile saline and reapply additional sheets over previous applications as necessary.
Please visit our Ordering page for details.
OASIS® Wound Matrix has gained formal/informal Medicare coverage in all 50 states and US territories. Coverage provides relevant CPT® codes for the procedure and HCPCS codes for the products. Because specific insurance coverage varies among providers and coverage frequently changes, patients should check with insurers for coverage verification and additional information. Please visit our Reimbursement page for details.
OASIS® Wound Matrix is supplied sterile in peel-open packages intended for one-time use, with a convenient shelf life of 24 months from the date of manufacture. It should be stored in a clean, dry location at room temperature.
OASIS® Wound Matrix is well tolerated in most patients. However, patients may experience the following complications: infection, chronic inflammation, allergic reaction, or excessive redness, pain, swelling, or blistering. If any of these side effects occur, remove OASIS® Wound Matrix from the wound. Initial application of wound dressings may be associated with transient, mild, localized inflammation.
Please review the “Precautions” section of the OASIS® Wound Matrix Instructions for Use.
OASIS® Wound Matrix is safe to reapply as many times as necessary until the wound is fully epithelialized or significant granulation has occurred. Discontinue use in the event of infection, chronic inflammation, allergic reaction, or excessive redness, pain, swelling,
or blistering.


References: 1. Hodde JP, Janis A, Hiles M. Effects of sterilization on an extracellular matrix scaffold: part II. Bioactivity and matrix interaction. J Mater Sci Mater Med. 2007;18(4):545-550. 2. Data on file. Cook Biotech, Inc. 3. MacNeil S. What role does the extracellular matrix serve in skin grafting and wound healing? Burns. 1994;20(Suppl 1):S67-S70. 4. Clark RA. Basics of cutaneous wound repair. J Dermatol Surg Oncol. 1993;19(8):693-706.

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