Triple-layer Strength Backed by Data
 

The clinical significance of these data has not
been established

 

Demonstrated durability versus single-layer
OASIS® Wound Matrix1

Tri-layer and single-layer matrix in murine model
Day 6 after second application

Demonstrated durability versus single-layer OASIS<sup ></sup>® Wound Matrix

The SIS matrix was associated with…
 

Substantial vascular infiltration in an animal model

When compared to ORC/collagen, the SIS environment was associated with more blood vessel ingrowth in a murine model2

Demonstrated durability versus single-layer OASIS<sup ></sup>® Wound Matrix

Fluorescence microangiography showed the presence of revascularization with the SIS environment versus oxidized regenerated cellulose/collagen (ORC)2

  • SIS environment revealed substantial blood vessel ingrowth, in contrast to the minimal blood vessel ingrowth observed with the regenerated matrix2

 

The SIS matrix was associated with…
 

Evident cellular infiltration in an animal model

When compared to ORC/collagen, the SIS environment demonstrated an association with more cellular infiltration in a murine model2

Demonstrated durability versus single-layer OASIS<sup ></sup>® Wound Matrix

Hematoxylin- and eosin- (H&E) stained sections of SIS and regenerated matrix discs showed cellular infiltration 21 days after subcutaneous implantation into mice2

 

Study design2

The mouse subcutaneous implant method was used for the investigation of in vivo angiogenesis and cellular infiltration.

  • SIS matrix and oxidized regenerated cellulose/collagen sheets were made into
    4-layer discs that were then implanted subcutaneously into mice (10 SIS,
    10 regenerated matrix, 2 implants per mouse). Samples were rehydrated before implantation
  • Vessel ingrowth was assessed at Day 21 after implantation, using fluorescence microangiography and histology

 

 

 

 References: 1. Data on file. In vivo data. Smith & Nephew, Inc. 2. Data on file. Cook Biotech, Inc.

 




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