Sophisticated Structure

OASIS® Wound Matrix is a naturally derived structure that helps support the body's own wound closure mechanisms

OASIS® Wound Matrix is an intact matrix naturally derived from porcine small intestinal submucosa (SIS), indicated for the management of wounds

OASIS Wound Matrix is an intact matrix naturally derived
  • SIS technology is proven to support the body’s own tissue repair mechanisms critical to wound closure1,2

  • SIS is the most widely studied and published biomaterial, featured in more than 990 scientific publications1

    • SIS research currently includes more than 340 human studies1


A 3-dimensional, bioresorbable extracellular matrix (ECM), OASIS® Wound Matrix is incorporated and absorbed into the wound

A 3-dimensional

  • In a healthy body, the ECM is the structural component that surrounds cells and binds them in tissue3,4




OASIS® Wound Matrix versus regenerated matrix:
a natural difference

Unlike oxidized regenerated cellulose/collagen (ORC), OASIS® Wound Matrix retains its natural structure1,2,5

Natural (SIS) Structure

Regenerated Matrix A Natural Difference

  • Minimally processed and sterilized using a proprietary method that allows long-term storage of the structure without compromising its ability to support the body’s own tissue repair mechanisms2


Regenerated Matrix ORC/Collagen

  • Freeze-dried sponge prepared from bovine collagen and ORC. Does not contain proteoglycans or glycosaminoglycans (GAGs)5

OASIS® Wound Matrix retains multiple components found in human dermis5

OASIS Wound Matrix retains multiple components essential for healing

*Components identified are in vivo (nonhuman) and/or in vitro.
Present in SIS cultured with cells.
GAGs=glycosaminoglycans; HSPG=heparan sulfate proteoglycan


OASIS® Wound Matrix is always on hand when needed

  • Long 2-year shelf life keeps OASIS® Wound Matrix on hand for nonhealing wounds
  • No advance ordering or preparation required
  • Room temperature and on-the-shelf storage
  • Convenient for use in a variety of settings, including long-term, outpatient,
    and at-home care

OASIS® Wound Matrix is indicated for the management of wounds including:

  • Partial- and full-thickness wounds
  • Pressure ulcers
  • Venous ulcers
  • Chronic vascular ulcers
  • Tunneled, undermined wounds
  • Diabetic ulcers
  • Trauma wounds
    • Abrasions
    • Lacerations
    • Second-degree burns
    • Skin tears
  • Draining wounds
  • Surgical wounds
    • Donor sites/grafts
    • Post-Mohs' surgery
    • Post-laser surgery
    • Podiatric
    • Wound dehiscence

CONTRAINDICATIONS: This device is derived from a porcine source and should not be used in patients with known sensitivity to porcine material.

This device is not indicated for use in third-degree burns.

References: 1. Data on file. Cook Biotech, Inc. 2. Hodde JP, Janis A, Hiles M. Effects of sterilization on an extracellular matrix scaffold: part II. Bioactivity and matrix interaction. J Mater Sci Mater Med. 2007;18(4):545-550. 3. MacNeil S. What role does the extracellular matrix serve in skin grafting and wound healing? Burns. 1994;20 Suppl 1:S67-S70. 4. Clark RA. Basics of cutaneous wound repair. J Dermatol Surg Oncol. 1993;19(8):693-706. 5. Data on file, Cook Biotech, Inc. 6. Gelse K, Pöschl E, Aigner T. Collagens—structure, function, and biosynthesis. Adv Drug Deliv Rev. 2003;55(12):1531-1546. 7. Frantz C, Stewart KM, Weaver VM. The extracellular matrix at a glance. J Cell Sci. 2010;123(Pt 24):4195-4200. 8. Hodde JP, Johnson CE. Extracellular matrix as a strategy for treating chronic wounds. Am J Clin Dermatol. 2007;8(2):61-66. 9. Chen WY, Abatangelo G. Functions of hyaluronan in wound repair. Wound Repair Regen. 1999;7(2):79-89. 10. Badylak SF. The extracellular matrix as a scaffold for tissue reconstruction. Semin Cell Dev Biol. 2002;13(5):377-383.

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OASIS is a registered trademark of Cook Biotech, Inc.
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