Sophisticated Structure

OASIS® Ultra provides triple the structure for
challenging wounds

Three layers of bioresorbable extracellular matrix (ECM) incorporate increased structure into the wound

OASIS Wound Matrix is an intact matrix naturally derived

  • In a healthy body, the ECM is the structural component that surrounds cells and binds them in tissue1,2


Naturally derived, intact porcine small intestinal submucosa (SIS)

  • SIS technology is proven to help support the body’s own tissue repair mechanisms critical to wound closure3,4

    • SIS is the most widely studied and published biomaterial, featured in more than 990 scientific publications3

    • SIS research currently includes more than 340 human studies3


Triple-layer structure for improved fixation5

Difference between OASIS Wound Matrix and OASIS Ultra


Designed with surgeons in mind

  • Extra thickness offers easier handling and application

  • Easy to trim to the exact size and shape of the wound

  • Three layers strong allow for easy fixation, including sutures and staples (if indicated)


Retains multiple components found in the human dermis6

  • OASIS® Ultra is minimally processed and sterilized through the use of a proprietary method that retains key collagen and non-collagen components4,6


OASIS Wound Matrix is an intact matrix naturally derived
*Components identified in vivo (nonhuman) and/or in vitro.
Present in SIS cultured with cells.
GAGs=glycosaminoglycans; HSPG=heparan sulfate proteoglycan


Designed specifically for a broad range of challenging wounds

OASIS Wound Matrix is an intact matrix naturally derived

OASIS® Ultra is indicated for the management of:

  • Partial-and full-thickness wounds
  • Pressure ulcers
  • Venous ulcers
  • Chronic vascular ulcers
  • Tunneled, undermined wounds
  • Diabetic ulcers
  • Trauma wounds
    • Abrasions
    • Lacerations
    • Second-degree burns
    • Skin tears
  • Draining wounds
  • Surgical wounds
    • Donor sites/grafts
    • Post-Mohs' surgery
    • Post-laser surgery
    • Podiatric
    • Wound dehiscence

CONTRAINDICATIONS: This device is derived from a porcine source and should not be used in patients with known sensitivity to porcine material.

This device is not indicated for use in third-degree burns.

References: 1. MacNeil S. What role does the extracellular matrix serve in skin grafting and wound healing? Burns. 1994;20(Suppl 1):S67-S70. 2. Clark RA. Basics of cutaneous wound repair. J Dermatol Surg Oncol. 1993;19(8):693-706. 3. Data on file. Cook Biotech, Inc. 4. Hodde JP, Janis A, Hiles M. Effects of sterilization on an extracellular matrix scaffold: part II. Bioactivity and matrix interaction. J Mater Sci Mater Med. 2007;18(4):545-550. 5. Data on file. In vitro data. Healthpoint Biotherapeutics, Ltd. 6. Data on file. Cook Biotech, Inc. 7. Gelse K, Pöschl E, Aigner T. Collagens—structure, function, and biosynthesis. Adv Drug Deliv Rev. 2003;55(12):1531-1546. 8. Frantz C, Stewart KM, Weaver VM. The extracellular matrix at a glance. J Cell Sci. 2010;123(Pt 24):4195-4200. 9. Hodde JP, Johnson CE. Extracellular matrix as a strategy for treating chronic wounds. Am J Clin Dermatol. 2007;8(2):61-66. 10. Chen WY, Abatangelo G. Functions of hyaluronan in wound repair. Wound Repair Regen. 1999;7(2):79-89. 11. Badylak SF. The extracellular matrix as a scaffold for tissue reconstruction. Semin Cell Dev Biol. 2002;13(5):377-383.

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OASIS is a registered trademark of Cook Biotech, Inc.
All trademarks acknowledged. TM1566-0215

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